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FLASH GENE
Symbol KCTD10 contributors: SGE/npt - updated : 12-07-2013
HGNC name potassium channel tetramerisation domain containing 10
HGNC id 23236
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselsaorta   
Digestiveesophagus   highly
 mouth   highly
Respiratoryrespiratory tracttrachea  highly
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one BTB (POZ) domain
    • conjugated PhosphoP
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Kctd10 (98.4pc)
    intraspecies homolog to PDIP1
    Homologene
    FAMILY
  • polymerase delta-interacting protein 1 (PDIP1) gene family
  • KCTD10/KCTD13/TNFAIP1 family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • K+ channel activity
  • may be associated with DNA synthesis and cell proliferation (Wang 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text potassium ion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with the small subunit of DNA polymerase delta and PCNA (Wang 2009)
  • TNFAIP1 overexpression resulted in ubiquitin-mediated degradation of KCTD10 proteins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other
  • KCTD10 (V206VT->C and i5642G->C) variants may contribute to the variation in HDL-cholesterol concentrations, particularly in subjects with high carbohydrate intakes (Junyent 2009)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS