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FLASH GENE
Symbol SPATA13 contributors: mct/npt/pgu - updated : 10-12-2015
HGNC name spermatogenesis associated 13
HGNC id 23222
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   highly
Lymphoid/Immunespleen   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an APC binding region
  • a Dbl homolgy domain
  • a Src homology 3 domain
  • a Pleckstrin homology domain
    • HOMOLOGY
    interspecies homolog to murine Spata13 (87.1pc)
    homolog to rattus Spata13 (87.1pc)
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • may be implicated in spermatogenesis
  • plays an important role in cell migration
  • regulates actin cytoskeletal organization and is required for hepatocyte growth factor-induced cell migration, in cooperation with PPP1R9B and APC
  • functions as a Cdc42 exchange factor
  • having a GEF activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with APC
  • interacts with Neurabin2/Spinophilin, a scaffold protein that binds to Filamentous actin (F-actin)
  • three regulators of the actin cytoskeleton--AMOTL2, SPATA13 and FLII--interact with PHLDB2 (pMID: 23525008
    • cell & other
    REGULATION
    activated by truncated mutant APC and is required for aberrant migration of colorectal tumor cells
    induced by APC that stimulates the GEF activity of ARHGEF4 and SPATA13 and thereby regulates cell adhesion and migration
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS