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FLASH GENE
Symbol HBP1 contributors: mct/npt/pgu - updated : 29-05-2010
HGNC name HMG-box transcription factor 1
HGNC id 23200
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • HMG-box
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • cell cycle inhibitor and HMG-box transcription repressor
  • playing a role in tissue maintenance
  • playing roles in cell cycle progression and tumor suppression
  • transcriptional repressor participates in RAS- and MAPK14-induced premature senescence
  • participating with MAPK14 together in a G1 regulatory network
  • regulated proliferation and senescence and inhibited Wnt signaling
  • may be a molecularly and clinically relevant regulator of breast cancer transitions that eventually lead to poor prognosis
  • transcriptional repressor that negatively regulate the cell cycle
  • important effector in oncogene-induced premature senescence, a tumor suppressing mechanism
  • HMG-containing repressor transiently induced during differentiation of several cell lineages
  • temporally coordinates expression of genes involved in stratification, leading to the formation of the skin barrier
  • CELLULAR PROCESS cell cycle
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacts with both the transactivation domain as well as the C terminus of MYC (expression of HBP1 inhibits MYC transactivational activity at least partly by preventing MYC binding to target gene promoters) (Escamilla-Powers 2010)
  • cell & other
    REGULATION
    repressed by directly repressed by TP63
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer is correlated with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS