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FLASH GENE
Symbol TRAPPC6B contributors: mct - updated : 12-07-2021
HGNC name trafficking protein particle complex 6B
HGNC id 23066
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Nervousbrain     Homo sapiensFetal
 brain     Homo sapiensAdult
 spinal cord     Homo sapiensAdult
Urinarybladder    
 kidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , heteromer , dimer
HOMOLOGY
interspecies homolog to rattus Trappc6b (98.7 pc)
homolog to murine Trappc6b (97.5 pc)
Homologene
FAMILY
  • TRAPP small subunits family
  • BET3 subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in vesicle-mediated transport
  • role of TRAPPC6B in human brain development
  • RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text ER-Golgi transport
    PATHWAY
    metabolism
    signaling
    a component
  • part of the multisubunit TRAPP (transport protein particle) complex (Kummel 2005)
  • core subunit of the complex TRAPP I
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRAPPC3 in heterodimer (Kummel 2005)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEDMEBA
    Susceptibility to restless legs syndrome
    Variant & Polymorphism other
  • c.485G > A transition of the TRAPPC6B gene segregates with the RLS2 haplotype
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS