SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton
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| co-localizes with the Golgi apparatus and the microtubule-organizing center (MTOC), which indicates that mutations in this gene may impair cytokine trafficking and secretion |
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NLRP7 and KHDC3L localize to the oocyte cytoskeleton and are polar and absent from the cell-to-cell contact region in early preimplantation embryos |
basic FUNCTION
| maternal effect gene, responsible for recurrent spontaneous abortions, stillbirths and intrauterine growth retardation |
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feedback regulator of interleukin-1beta secretion |
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regulating expression of imprinted genes on several chromosomes |
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inhibits caspase-1-dependent interleukin-1beta secretion |
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PYRIN-containing APAF-1-like protein, feedback regulator of caspase-1-dependent interleukin-1 beta secretion |
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could cause recurrent fetal loss by leading to defective oocytes or/and by creating a hostile maternal environment for embryonic development in the Fallopian tubes and the uterine cavity |
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play important roles in both mammalian innate immune system and reproductive system |
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regulates multiple important biological processes, especially during embryonic development |
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KHDC3L, NLRP7 having roles in the integrity of the oocytes, post-zygotic divisions, and cell-lineage differentiation |
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NLRP7 contributes likely to in vitro decidualization of endometrial stromal cells |
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NLRP7 is likely a primate-specific multitasking gene to maintain endometrial hemostasis and reproductive success |
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evidence of its role in inflammasome regulation and its implication in human reproductive diseases. |
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NLRP7 increases trophoblast proliferation and decreases their differentiation, both in normal and tumor conditions |
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can function in an inflammasome-dependent or independent pathway |