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FLASH GENE
Symbol IFT74 contributors: mct - updated : 14-06-2022
HGNC name intraflagellar transport 74 homolog (Chlamydomonas)
HGNC id 21424
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumear    
Reproductivemale systemtestis    Mus musculus
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatocyte Mus musculus
Reproductivespermatogonia Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a calponin-homology domain within the IFT81 N-terminus and the highly basic N-terminus of IFT74 form a module for IFT of tubulin ( , and N terminus of IFT74 may be involved in, but is not required for, tubulin entry into flagella, but is required for association of IFT-A and IFT-B at the base of the flagellum and flagellar import of IFT-A
  • coiled-coil domains
  • two tyrosine phosphorylation sites, one for cAMP/cGMP proteine kinase
  • HOMOLOGY
    interspecies homolog to murine Ift74 (86.3pc)
    homolog to rattus Ift74 (87.5pc)
    homolog to the intraflagellar transport protein IFT-74/72 of Chlamydomonas
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    basic FUNCTION
  • serves potentially as a transcriptional regulator of proliferation and adhesion-associated genes in early stage male germ-line cells in the testis
  • two core IFT proteins IFT74 and IFT81 form a tubulin-binding module
  • together, the IFT81 and IFT74 N-termini are crucial for flagellar assembly, and are likely to function as the main module for IFT of tubulin
  • may be a potential genetic factor affecting male reproduction in man
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFT52 binds directly to four other IFT-B subunits, IFT81/74/27/HSPB11
  • IFT74 and IFT81 interact directly through central and C-terminal coiled-coil domains, and the N termini of these proteins form a tubulin-binding module important for ciliogenesis
  • together, the IFT81 and IFT74 N-termini are crucial for flagellar assembly, and are likely to function as the main module for IFT of tubulin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BBS22 , SPGF58 , JBTS40
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice deficiency in Ift74 gene in male germ cells were infertile with low sperm count and immotile sperm