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FLASH GENE
Symbol FOXN4 contributors: mct/ - updated : 14-10-2015
HGNC name forkhead box N4
HGNC id 21399
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
Nervousbrain     Rattus norvegicus
 spinal cord     Rattus norvegicus
Reproductivemale systemtestis   
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentralgray matter   Rattus norvegicus
Nervouscentralwhite matter   Rattus norvegicus
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte Rattus norvegicus
Nervousneuron Rattus norvegicus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a fork-head DNA-binding domain
  • a domain between AAs 402 and 455 is necessary for FOXN4 transcriptional activity in the retina (pMID: 21701787)
  • HOMOLOGY
    intraspecies paralog to FOXN1
    Homologene
    FAMILY
  • winged-helix/forkhead family of transcription factors
  • N-family forkhead transcription factors
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional regulator involved in development
  • regulates the expression of NR4A2, a nuclear receptor that is associated with familial Parkinson's disease
  • forkhead/wing helix transcription factor with a role in the specification of cells in retinogenesis and spinal neurogenesis
  • is required for retinal ganglion cell distal axon patterning
  • may have a non-cell-autonomous role critical for alveologenesis during lung development
  • transcription factor involved in developing spinal cord and spinal neurogenesis, and implied important roles in the central nervous system (CNS)
  • might play important roles in CNS pathophysiology after spinal cord injury (SCI)
  • is a key regulator in a variety of biological processes during development
  • plays an essential role in the genesis of horizontal and amacrine neurons from neural progenitors in the vertebrate retina
  • FOXN4 exhibited substantial thymopoietic activity
  • FOXN4, RORB and their downstream effector PTF1A, have been shown to be indispensable intrinsic regulators for the differentiation of amacrine and horizontal cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • DLL4 is directly activated by FOXN4 via phylogenetically conserved enhancers and DLL4 can partly mediate the FOXN4 function by serving as a major NOTCH1 ligand to expand the progenitor pool and limit photoreceptor production
  • RORB and FOXN4 synergistically induce PTF1A expression, suggesting a central role for RORB in a transcriptional hierarchy that directs this interneuron differentiation pathway
  • MEIS1 regulates FOXN4 expression during retinal progenitor cell differentiation
  • mosaic expression of FOXN4 and proneural factors may serve as the trigger to initiate asymmetric DLL4-NOTCH1 and subsequent BMP/TGFB1 signaling events required for neuronal diversity in the V2 interneurons domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS