basic FUNCTION
| receptor activity, mediating lysis by activating cytotoxic cells |
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triggers ERK phosphorylation and activation |
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functioning as a self-ligand and its homophilic interaction regulates NK cell cytolytic activity |
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SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses |
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is a self-ligand and has both activating and inhibitory functions in Natural Killer cells |
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plays an inhibitory role in human monocytes to control proinflammatory immune responses |
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natural killer T (NKT) cells and innate CD8(+) T cell development can be regulated in a SAP-dependent and -independent fashion by SLAMF receptors, in which SLAMF1, SLAMF6, and SLAMF8 affect development of NKT cells, and CD84, SLAMF7, and SLAMF8 affect the development of innate CD8(+) T cells |
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in NK cells, SLAMF7 signaling induces cytolytic function of NK cells against targets whereas in B cells SLAMF7 induces proliferation and autocrine cytokine production |