basic FUNCTION
| may be a transcriptional coactivator |
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A-type-lamin-associated, inner nuclear membrane protein, involved in nuclear structure organization |
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critical for normal nuclear envelope morphology |
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is required for myogenic differentiation (Huber 2009) |
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INM protein LEMD2 is concomitantly expressed with A-type lamins in various cell types but is lacking in inverted nuclei of rod cells |
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LEMD2 and the ESCRT-II/ESCRT-III hybrid protein CHMP7, work together to recruit additional ESCRT-III proteins to holes in the nuclear membrane |
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LEMD2 is a conserved nuclear site-specific adaptor that recruits CHMP7 and downstream ESCRT factors to the nuclear envelope |