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FLASH GENE
Symbol PNLDC1 contributors: mct - updated : 22-10-2018
HGNC name poly(A)-specific ribonuclease (PARN)-like domain containing 1
HGNC id 21185
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
poly-A specific exoribonuclease (PARN) domain
HOMOLOGY
interspecies homolog to murine LOC240023
intraspecies homolog to PARN
Homologene
FAMILY ribonuclease H-like superfamily
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,nucleus
text
  • localized mainly in the ER
  • basic FUNCTION
  • transcriptional repressor activity
  • negative regulation of transcription
  • is a novel deadenylase expressed specifically in cell types which share regulatory mechanisms required for multipotency maintenance
  • PNLDC1 shows limited conservation compared to PARN and represents an evolutionary related but distinct group of enzymes
  • is a novel deadenylase expressed specifically in cell types which share regulatory mechanisms required for multipotency maintenance, but it could be involved both in posttranscriptional regulation through deadenylation and genome surveillance during early development
  • is likely a mammalian piwi-interacting RNA biogenesis factor that protects the germline genome and ensures normal sperm production
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • its expression in differentiated cells, is suppressed through methylation of its promoter by the de novo methyltransferase DNMT3B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS