basic FUNCTION
| involved in ER-related apoptotic pathway |
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suppresses the unfolded protein response by inhibiting phosphorylation of eIF2alpha |
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involved in the biogenesis of endosomes |
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regulates the structure and function of the endosomes through RAB5-dependent processes |
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by modulating the receptor density on the cell surface, can modulate the cell response to the extracellular stimulation |
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via RAB5, could also regulate the presence of membranous P-glycoprotein, which confers multi-drug resistance to cancer therapy |
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by modulating the endosomal and/or lysosomal pathway, PLEKHF1 and PLEKHF2 may function as a membrane organizer that controls (at a cellular or subcellular level) the space and time of intracellular signal propagation |
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is more functionally related to early endocytosis and early endosome recycling activity |
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controls receptor trafficking and fluid-phase transport through early endosomes by facilitating endosome fusion in concert with EEA1 |