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FLASH GENE
Symbol ELP3 contributors: mct/npt - updated : 05-01-2017
HGNC name elongation protein 3 homolog (S. cerevisiae)
HGNC id 20696
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonamygdala  
Reproductivefemale systemuteruscervix  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • GNAT domain playing a significant role in axon targeting and synaptic communication (Simpson 2009)
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Elp3
    homolog to S.cervisiae ELP3
    Homologene
    FAMILY
  • ELP3 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text predominantly found in nucleus but also localized to the nucleoli and in the cytoplasm
    basic FUNCTION
  • N-acetyltransferase activity
  • may have a role for the elongator complex during transcription
  • critical regulator of axon targeting and synaptic communication (Simpson 2009)
  • involved in RNA processing (Simpson 2009)
  • promotes acetylation and counteracts HDAC6-mediated deacetylation of tubulin alpha (Creppe 2009)
  • is the acetylase component of the complex and is known to play a key role in histone acetylation
  • ELP3, and possibly the ELONGATOR complex may play a role in mitochondrial function, as well as in actin organisation and cell motility
  • having functions in HSP70-2 gene transcriptional elongation in cells (Han 2007)
  • ELP1, ELP2, ELP3, ELP4, ELP5, ELP6 plays vital roles in gene regulation
  • drives Wnt-dependent tumor initiation and regeneration in the intestine
  • implicated in translational regulation via modification of tRNA at the wobble position
  • ELP3 function is critical for translational efficiency of the genes
  • CELLULAR PROCESS nucleotide, transcription, elongation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the six subunits of the elongator complex (IKAP, ELP3, p38, p30, ELP4 and p95)
  • part of the RNA polymerase II complex (Simpson 2009)
  • subunit of the Elongator (Han 2007)
  • core Elongator complex formed by IKBKAP, ELP2, and ELP3 was rather stable, whereas ELP4, ELP5, and ELP6 might loosely contact and work together with the core Elongator to regulate cell functions
  • catalytic subunit of the Elongator complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting directly with RNAPII
  • ELP5 is required for the integrity of Elongator and directly connects ELP3 to ELP4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    with CCDC25, DLC1, PROSC, SH2D4A, and SORBS3 in Hepatocellular carcinoma (HCC) from patients with poor outcomes
    tumoral     --low  
    promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal carcinomas (IDCs)
    Susceptibility
  • to amyotropic lateral sclerosis (ALS)
  • to motor neuron degeneration
  • Variant & Polymorphism SNP association of ELP3 variants with motor neuron degeneration (Simpson 2009)
    Candidate gene
    Marker
    Therapy target potential therapeutic target for treatment of ALS (Simpson 2009)
    ANIMAL & CELL MODELS
  • depletion of Elp3 in embryonic stem cell (ESC) led to aberrant cell cycle progression, along with reduced expression of genes for pluripotency