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FLASH GENE
Symbol REN contributors: mct/npt - updated : 02-09-2008
HGNC name renin
HGNC id 9958
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
Urinarybladder    
 kidneynephronrenal capsuleglomerulus 
cells
SystemCellPubmedSpeciesStageRna symbol
Urinarymesenchymal cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
  • peptidase A1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text secreted
    basic FUNCTION
  • aspartic endopeptidase, angiotensin-forming enzyme, converting angiotensinogen to angiotensin I
  • catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure
  • primary function of renin is the hydrolytic cleavage of angiotensinogen to angiotensin, with the subsequent stimulation of aldosterone production (Zivna 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PCBP1, ELAVL1, and HADHB
  • cell & other
    REGULATION
    induced by low blood pressure and hypoxia
    ASSOCIATED DISORDERS
    corresponding disease(s) RTD4 , UAKD2
    Susceptibility to arterial hypertension
    Variant & Polymorphism other polymorphisms in the kidney enhancer associated with arterial hypertension
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS