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FLASH GENE
Symbol ATF7IP contributors: mct/pgu - updated : 13-09-2013
HGNC name activating transcription factor 7 interacting protein
HGNC id 20092
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix highly
 male systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • AAA ATPase containing Von Willebrand factor type A (VWA) domain
  • many ser/thr-rich domain and repeats
  • two evolutionarily conserved domains directly interact with Sp1 and the general transcriptional apparatus
  • SUMO-interacting motifs (SIMs) that are composed of a hydrophobic core and a stretch of acidic AAs, playing an important role in the binding to SUMO3
  • HOMOLOGY
    interspecies ortholog to murine Atf7ip
    Homologene
    FAMILY MCAF/AM family proteins
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • coactivator-like activity
  • negative or positive regulation of transcription in association with MBD1 or Sp1 proteins
  • required for transcriptional repression and heterochromatin formation by MBD1, together with the involvement of SETDB1
  • playing a role in epigenetic control
  • involved in Sp1-dependent maintenance of telomerase activity in cancer cells
  • may facilitates telomerase expression by Sp1, which may be a common mechanism in proliferative cancer cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with MBD1/SETDB1 (complex facilitating the formation of heterochromatic domains, and emphasizing the role of MCAF/AM family proteins in epigenetic control)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the transcriptional repression domain of MBD1 to form the repressive complex
  • interacts with SUMO2/3 and SUMO1, with a preference for SUMO2/3
  • ATF7IP and ATF7IP2 interact with MBD1, SETDB1, and Sp1 via two evolutionarily conserved distinct domains
  • a transcriptional positive regulator when coupled with Sp1
  • MBD1-MCAF interferes with Sp1-mediated transactivation
  • interact with SUMOs, which forms complexes with either the methyl-CpG-binding protein MBD1 or SETDB1, which trimethylates histone H3 at lysine 9 (H3-K9)
  • regulator of TERT expression
  • RSF1 and ATF7IP are very likely interacting with SP110 during the process of viral infections
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to testicular germ cell tumor (TGCT)
    Variant & Polymorphism other
  • association between genetic marker rs4617646 and TGCT risk
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS