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FLASH GENE
Symbol ABCC5 contributors: - updated : 20-09-2006
HGNC name ATP-binding cassette, sub-family C (CFTR/MRP), member 5
HGNC id 56
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 mouth   highly
Nervousbrain    
 nervecranial nerve  highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ATP binding, each containing highly conserved Walker motifs
  • two transmembrane (2TM) domains (2 x 6 segments)
  • HOMOLOGY
    interspecies homolog to C.elegans F14F4.3B
    Homologene
    FAMILY
  • ATP binding cassette superfamily, subfamily C (CFTR/MRP)
  • CATEGORY signaling , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putative glutathione (GSH) conjugate (GS-x) pump or canalicutar multispecific anion transporter, involved in drug resistance (thiopurine to potecan, doxorubicin)
  • acting as a multispecific organic anion pump which can transport nucleotide analogs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS