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FLASH GENE
Symbol ATG14 contributors: mct - updated : 07-03-2015
HGNC name ATG14 autophagy related 14 homolog (S. cerevisiae)
HGNC id 19962
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal zinc finger motif
  • a central coiled-coil domain (CCD) (specifically binds to Beclin 1 through its CCD)
  • a domain organization similar to Atg14 in yeast
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text
  • specific to the autophagy complex and localizes to the endoplasmic reticulum (ER)
  • basic FUNCTION
  • required for suppression of the autophagy-mediated intracellular survival of Salmonella typhimurium in mammalian cells
  • involved in regulatory signaling pathway that positively controls autophagy through Beclin 1 (Sun 2008
  • ATG14-dependent appearance of PI3P in the ER makes this organelle the platform for autophagosome formation
  • role of ATG14 in autophagosome formation
  • function of ATG14 in the endocytic trafficking pathway wherein ATG14 binds to and colocalizes with the fusogenic SNARE effector protein Snapin to facilitate endosome maturation
  • functions as a multivalent trafficking effector that regulates endosome maturation as well as autophagosome formation, reflecting the complexity of the crosstalk between autophagic and endocytic vesicle trafficking in higher eukaryotes
  • autophagy-essential gene present only in the proautophagy PIK3C3 complex
  • promotes membrane tethering and fusion of autophagosomes to endolysosomes
  • key role of ATG14 in controlling autophagosome fusion with a lysosome
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major component of the Beclin 1–PI3KC3 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • competes with UV radiation resistance associated gene product (UVRAG) for interaction with BCN1, and the complex formation of Barkor and BCN1 is required for their localizations to autophagosomes
  • BECN1 interacting protein (might promote the translocation of BECN1 from the trans-Golgi network to autophagosomes)
  • BECN1 coiled coil domain (CCD) serves as an interaction platform for assembly of distinct ATG14- and UVRAG-containing complexes to modulate PIK3C3 activity
  • directly interacts with BECN1 through its coiled-coil domain and enhances phosphatidylinositol 3-phosphate kinase class III (PI3KC3) activity to induce autophagosome membrane nucleation
  • specifically binds to Snapin and this interaction effectively facilitates endosomal maturation without affecting autophagic cargo degradation
  • actin filaments colocalized with ATG14, BECN1/Beclin1 and PtdIns3P-rich structures, and some of them have a typical omegasome shape stained with the double FYVE domain or ZFYVE1
  • is a new target gene of FOXOs and the core clock machinery, and this gene plays an important role in hepatic lipid metabolism
  • dictates the differential regulation (either inhibition or activation) of different PIK3C3 complexes in response to glucose starvation
  • ER-resident SNARE protein syntaxin 17 (STX17) binds ATG14 and recruits it to the ER-mitochondria contact site
  • is critical in controlling an autophagy-dependent phosphorylation of BECN1
  • DACT1 enhances the ATG14-BECN1-PIK3C3 complex formation and PIK3C3 kinase activity
  • NRBF2 may interact with the ATG14-containing BECN1-PIK3C3 protein complex to modulate protein-protein interactions within the complex, leading to suppression of PIK3C3 activity, autophagosome biogenesis, and autophagic flux
  • ATG14 binds to the SNARE core domain of STX17 through its coiled-coil domain, and stabilizes the STX17-SNAP29 binary t-SNARE complex on autophagosomes
  • ATG14-STX17-SNAP29 interaction mediates autophagosome-lysosome tethering and fusion events, thus revealing a novel function of ATG14 in the later steps of the autophagy pathway
  • directly binds to the STX17-SNAP29 binary complex on autophagosomes and promotes STX17-SNAP29-VAMP8-mediated autophagosome fusion with lysosomes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    leads to autophagy activation and increased number and enlarged volume of autophagosomes (Sun 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potential target for drug development in the treatment of human diseases implicated in autophagic dysfunction
    ANIMAL & CELL MODELS