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FLASH GENE
Symbol DOK4 contributors: - updated : 16-04-2005
HGNC name docking protein 4
HGNC id 19868
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 liver   highly
Endocrinepancreas    
Urinarykidney   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • pleckstrin homology and PTB
  • short carboxl-terminal tail containing a few tyrosine motifs
  • HOMOLOGY
    interspecies ortholog to murine Dok4
    intraspecies homolog to DOK5
    Homologene
    FAMILY DOK family
    CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be involved in the regulation of the immune response induced by T cells
  • signaling proteins with potential roles in insulin and IGF-1 action
  • activates MAPK
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • insulin recptor binding
  • binding SH2 proteins like CRK, SRC, FYN
  • cell & other
    REGULATION
    Other tyrosine-phosphorylated in response to insulin and IGF-1
    dephosphorylated by a pervanate-inhibitable phosphatase
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS