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FLASH GENE
Symbol SEPHS1 contributors: mct - updated : 21-10-2010
HGNC name selenophosphate synthetase 1
HGNC id 19685
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrineplacenta    
Reproductivefemale systemplacenta   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
cell cycle     cell cycle, G2M, M exit
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine 1110046B24Rik
homolog to rattus LOC291314
homolog to drosophila patufet
intraspecies homolog to SEPHS2
Homologene
FAMILY
  • selenophosphate synthetase family
  • class II subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • able to affect cell viability upon ionizing radiation via modulation of TP53 activity
  • might be involved in cancer prevention in a TP53-dependent manner and could be applied to development of a novel cancer therapy
  • participates in pathways important for cell viability
  • participates in the regulation of oxidative stress and cell growth
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP and GTP binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS