SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,matrix
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| intracellular,cytoplasm,cytosolic
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| located in the nucleus as well as in the cytoplasm (PMID; |
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targeted to mitochondria where it forms granules that colocalize with foci of newly synthesized mtRNA next to mitochondrial nucleoids (PMID; |
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previously reported to localize in the cytosol, but an isoform of GRSF1 accumulates in discrete foci in the mitochondrial matrix (PMID; |
basic FUNCTION
| playing a role in the binding of RNAS containing the 14 bases G-rich element |
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mRNA-binding protein involved in translation activation |
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functions by selectively recruiting cellular and viral mRNAs containing 5prime UTR GRSF1 binding sites to polyribosomes, which is mediated through interactions with cellular proteins |
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implicated in the influenza viral life cycle, embryonic brain development and the regulation of apoptosis |
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functional component of several cellular signalling pathways as well as of the regulation of the cellular redox homeostasis |
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is a key regulator of posttranscriptional mitochondrial gene expression |
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regulates RNA processing in mitochondrial RNA granules |