Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TMEM47 contributors: mct - updated : 15-09-2012
HGNC name transmembrane protein 47
HGNC id
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine   
 liver    
Lymphoid/Immunespleen    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidneynephronrenal capsuleglomeruluslowly Homo sapiens
 kidneytubuleconvoluted tubule lowly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Urinarypodocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, perinatal
Text
  • expression of TM4SF10 peaked at postnatal day 4 and was virtually absent in adult kidneys
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four putative transmembrane domains
  • HOMOLOGY
    interspecies ortholog to C- elegans VAB-9
    Homologene
    FAMILY
  • PMP22/EMP/claudin protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • localizes at the basal-most region of podocyte precursors before the capillary loop stage, at some tubule precursors, and at the ureteric bud junction with S-shaped bodies
  • localized to the perinuclear region and translocated to the cell membrane after Cadherin appearance at cell-cell contacts
  • basic FUNCTION
  • functions during differentiation of podocytes and may participate in the maturation of cell junctions from simple adherens junctions to elaborate slit diaphragms
  • claudin-like proteins that function during junctional development
  • claudin-like cell junction protein that is transiently expressed during podocyte development where its expression is downregulated in differentiating podocytes coincident with the appearance of nephrin at the slit diaphragm
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting witrh FYN (may have a regulatory role in suppressing FYN activity)
  • interaction with FYB, a FYN adapter protein expressed in podocytes, and TMEM47 possibly through FYB, may regulate FYN activity
  • cell & other
    REGULATION
    Other its expression is temporally regulated during kidney development
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS