protein
| binds NEDD4 WW domains (positive roles of NDFIP1/NEDD4 in improving neuronal survival during brain injury) |
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can interact with WW domains of a number of NEDD4 family members |
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activate the catalytic activity of ITCH and of several other HECT ligases by binding to them |
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interacting with SLC11A2 (interacts with 2 WW domain-interacting proteins, NDFIP1 and NDFIP2) |
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physically and functionally associated with multiple components of the EGF signaling cascade, and their levels modulate the relative output of different signaling pathways |
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NDFIP1 is a critical mediator of SLC11A2 regulation particularly under iron restricted conditions |
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is an adaptor for the E3 ubiquitin ligase ITCH |
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PTEN secretion in exosomes required NDFIP1, an adaptor protein for members of the NEDD4 family of E3 ubiquitin ligases |
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enforces a requirement for CD28 costimulation by limiting IL2 production |
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nuclear trafficking of PTEN required both RAB5A as well as the E3 ligase adaptor protein NDFIP1 |
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NDFIP1 acts as an adaptor for UBE2L3 and ITCH |
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NDFIP1 is a sensor protein during cell injury and NDFIP1 up-regulation as a cue for BRAT1 ubiquitination by Nedd4 E3 ligases, followed by nuclear translocation of BRAT1 |
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NDFIP1 is primarily localized in the Golgi apparatus where it recruits NEDD4L to mediate the degradation of mature KCNH2 proteins during channel trafficking to the plasma membrane |
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important negative regulatory function for NEDD4L and NDFIP1 in IgE-dependent mast cell activity |
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NDFIP1 mediates the ubiquitination of NTRK2, resulting in receptor trafficking predominantly on RAB7A containing late endosomes, highlighting a pathway for NTRK2 degradation at the lysosome |