basic FUNCTION
| may be an E3 ubiquitin ligase |
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enhances both TGF-beta and bone morphogenetic protein (BMP) signaling |
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acting as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development |
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plays a crucial role in the transmission of transforming growth factor beta (TGFB)/activin and bone morphogenetic protein (BMP) signaling |
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critically required for TGF-beta signaling during epithelial to mesenchymal cell transition |
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regulates myoblast differentiation through both Smad-dependent and Smad-independent pathways |
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appears to regulate EGF signalling by modulating endocytosis of EGFR through interaction with AP2 complex |
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is not critical for regulating tumor growth per se, but is required for the early stages of cancer cell colonization at the sites of metastasis |
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can function as a SUMO-targeted ubiquitin ligase (STUBL) by ubiquitinating SUMO chains |
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is a novel STUBL that can trigger degradation of signal-induced polysumoylated proteins |
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facilitated NER by regulating the recruitment of XPC to UV-damaged DNA |
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ubiquitin ligase in the transforming growth factor beta (TGFb) pathway |
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its activity in transcriptional control may depend on the epigenetic context, defined by Polycomb repressive complexes and DNA methylation |