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FLASH GENE
Symbol RNF111 contributors: mct - updated : 02-09-2014
HGNC name ring finger protein 111
HGNC id 17384
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Lymphoid/Immunespleen    
Reproductivemale systemtestis   
Respiratorylung    
 respiratory tractlarynx   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • NLS in the N-terminal region
  • a RING finger domain
  • three successive SUMO-interacting motifs (SIMs) that mediate noncovalent interaction with poly-SUMO2
  • HOMOLOGY
    interspecies ortholog to murine Rnf111
    ortholog to rattus Rnf111_predicted
    Homologene
    FAMILY zinc finger family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • colocalized with SMAD7 in the cytoplasm
  • located in both the nucleus and the cytosol in mammalian cells
  • basic FUNCTION
  • may be an E3 ubiquitin ligase
  • enhances both TGF-beta and bone morphogenetic protein (BMP) signaling
  • acting as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development
  • plays a crucial role in the transmission of transforming growth factor beta (TGFB)/activin and bone morphogenetic protein (BMP) signaling
  • critically required for TGF-beta signaling during epithelial to mesenchymal cell transition
  • regulates myoblast differentiation through both Smad-dependent and Smad-independent pathways
  • appears to regulate EGF signalling by modulating endocytosis of EGFR through interaction with AP2 complex
  • is not critical for regulating tumor growth per se, but is required for the early stages of cancer cell colonization at the sites of metastasis
  • can function as a SUMO-targeted ubiquitin ligase (STUBL) by ubiquitinating SUMO chains
  • is a novel STUBL that can trigger degradation of signal-induced polysumoylated proteins
  • facilitated NER by regulating the recruitment of XPC to UV-damaged DNA
  • ubiquitin ligase in the transforming growth factor beta (TGFb) pathway
  • its activity in transcriptional control may depend on the epigenetic context, defined by Polycomb repressive complexes and DNA methylation
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
  • AXIN1 activates TGF-beta signaling by forming a multimeric complex consisting of SMAD7 and ubiquitin E3 ligase RNF111
  • stimulates renal tubular epithelial to mesenchymal cell transition through degradation of SMAD7
  • AP2M1 is an interacting partner of RNF111
  • RB1CC1/FIP200 is a novel positive regulator of TGFB signaling that functions as a substrate-selective cofactor of RNF111
  • binds and synergistically cooperates with RNF111 to activate SMAD3/SMAD4-dependent transcription
  • promoted ubiquitylation of SUMOylated XPC (xeroderma pigmentosum C) protein, a central DNA damage recognition factor in nucleotide excision repair (NER)
  • cell & other
    REGULATION
    repressed by TGF-beta
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mouse RNF111 genetically interacts with the TGF beta-like factor Nodal