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FLASH GENE
Symbol NAGPA contributors: - updated : 11-04-2007
HGNC name N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
HGNC id 17378
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 liver    
Lymphoid/Immunetonsils   highly
Nervousbrain    
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal signal sequence
  • a transmembrane region
  • six N-glycosylation potential sites
  • mono polymer homomer , tetramer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • removes a covering N-acetylglucosamine from the mannose-6-phosphate recognition marker on lysosomal acid hydrolases
  • can hydrolyses UDP-GlcNAc
  • involved in trafficking pathway and playing a crucial role in the process of lysosomal biogenesis
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    trafficking pathway
    a component homotetramer of two disulfide-linked homodimers
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by cleavage via the furin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS