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FLASH GENE
Symbol CSE1L contributors: mct - updated : 23-08-2015
HGNC name CSE1 chromosome segregation 1-like (yeast)
HGNC id 2431
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly Homo sapiens
 mouthtongue  highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
cells
SystemCellPubmedSpeciesStageRna symbol
 proliferating cell
Digestiveepithelial cell Homo sapiens
Digestivegoblet Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a nuclear localization signal (NLS)
HOMOLOGY
interspecies homolog to yeast chromosome segregation gene 1 (CSE1)
Homologene
FAMILY CSEL family
CATEGORY regulatory , transport
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
intracellular,nucleus
text shuttles between the nucleus and the cytoplasm
basic FUNCTION
  • involved in the cell cycle of mammalian cells and in apoptosis
  • transport factor necessary for recycling of importin-alpha from the nucleus to the cytoplasm
  • associating with a subset of p53 target promoters, cooperating with p53 to activate transcription of these genes by altering histone modification, specifically histone H3 lysine 27
  • regulates the secretion of colorectal cells and may rgulate the metastasis of colorectal cancer
  • may be involved in the "early" and "late" metastasis of tumor cells in tumorigenesis
  • required for the expression of genes promoting invasion and metastasis
  • plays roles in the regulation of the HR activity and in chromosome stability, and is likely responsible for controlling the HR activity by directly interacting with RAD51
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism cofactor
    signaling
    cofactor of p53
    a component
    INTERACTION
    DNA binding to chromatin
    RNA
    small molecule
    protein
  • binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1
  • is a negative regulator of CFTR-dependent fluid secretion
  • CSE1L associates with RAD51 in human cells, and negatively regulates the nuclear protein level of RAD51 under normal conditions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer (pMID: 23948303)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • urinary CSE1L deserves further evaluation for the screening of bladder cancer
  • immunohistochemical staining of nuclear CSE1L may be useful for the prognosis of bladder urothelial carcinomas
  • Therapy target
    ANIMAL & CELL MODELS