protein
| interacts with CD28, ERK, JNK, MAPK14 |
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negative regulator of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) pathway, rapidly and strongly activated by GCG |
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interacted with MAP3K7 and this interaction was enhanced by TNF or IL1 stimulation |
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directly interacted with MAP3K7-binding protein 1 (TAB1) and dephosphorylated TAB1 at Ser(438), leading to TAB1-MAP3K7 complex inactivation in T cells |
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acts as a MAP3K7 phosphatase to negatively regulate TNF- and IL1-induced NFKB1 activation |