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FLASH GENE
Symbol DUSP14 contributors: mct - updated : 26-08-2014
HGNC name dual specificity phosphatase 14
HGNC id 17007
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinethyroid   highly
Respiratoryrespiratory tracttrachea  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text highly in placenta and fetal lung, thymus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved centrally catalytic core
  • a single catalytic phosphatase domain
  • HOMOLOGY
    interspecies homolog to murine Dusp14
    Homologene
    FAMILY MKP family, non receptor class dual specificity subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • negative regulator of CD28 signaling
  • tyrosine/serine/threonine phosphatase activity
  • hydrolase activity
  • dephosphorylates ERK, JNK, MAPK14
  • is a negative regulator of TNF- and IL1-induced NFKB1 activation
  • negatively regulates TCR signaling and immune responses by inhibiting TAB1 activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CD28, ERK, JNK, MAPK14
  • negative regulator of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) pathway, rapidly and strongly activated by GCG
  • interacted with MAP3K7 and this interaction was enhanced by TNF or IL1 stimulation
  • directly interacted with MAP3K7-binding protein 1 (TAB1) and dephosphorylated TAB1 at Ser(438), leading to TAB1-MAP3K7 complex inactivation in T cells
  • acts as a MAP3K7 phosphatase to negatively regulate TNF- and IL1-induced NFKB1 activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS