SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
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text
| type 1 membrane protein |
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localizes to the Golgi apparatus and cycles early in the secretory pathway |
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localizes mainly to the ER and Golgi |
basic FUNCTION
| play a role as an intracellular lectin in the early secretory pathway |
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may retrieve misfolded glycoproteins back to the ER that have inadvertently escaped quality control in the ER |
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intracellular lectin that cycles between the endoplasmic reticulum (ER) and the Golgi apparatus, and is thought to act as a cargo receptor in the transport and sorting of glycoprotein |
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new role in the quality control of secretory proteins |
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shedding target and plays a role in phagocytosis in a shedding-dependent manner |
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regulates multiple steps of intracellular transport, including retrograde transport of immature glycoproteins from the Golgi to ER and phagocytosis of pathogens from the extracellular space to the endosome |
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LMAN2, LMAN2L, LMAN1, participate in the vectorial transport of glycoproteins via sugar-protein interactions |
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appears to be specifically required for the accumulation of GPRC5B in the Golgi complex and restriction of GPRC5B transport along the exosomal pathway |