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FLASH GENE
Symbol TGFBRAP1 contributors: mct - updated : 30-08-2011
HGNC name transforming growth factor, beta receptor associated protein 1
HGNC id 16836
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
multiple phosphorylation and myristoylation sites
HOMOLOGY
interspecies homolog to murine 3110018K12Rik
homolog to rattus LOC301373
Homologene
FAMILY
CATEGORY chaperone/stress , receptor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • receptor activity in the TGFB receptor signaling pathway
  • a partial cDNA of TGFBRAP1 could act as an inhibitor of TGFB signaling pathway
  • with VPS39, are nonredundant and essentially required for early embryonic development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with TGFBR2, SMAD4 and activated TGFBR1
  • four candidate target genes for NO66, SBNO1, TGFBRAP1, RIOK1, and RASGEF1A, which were the most significantly induced by exogenous NO66 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS