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FLASH GENE
Symbol DHX29 contributors: mct/npt - updated : 24-02-2010
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 29
HGNC id 15815
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonamygdala  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helicase associated region, DEAD/DEAH box helicase motif
  • HOMOLOGY
    interspecies homolog to murine Dhx29
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • ATP-dependent RNA helicase activity
  • involved in translation initiation on mammalian mRNAs with structured 5prime UTRs (Pisareva 2008)
  • DExH-box protein, facilitating translation initiation on mRNAs with structured 5prime untranslated regions (Stevenson 2008)
  • translation initiation factor, required for cell proliferation, that potentially can be exploited as a target to inhibit cancer cell growth (Parsyan 2009)
  • cytoplasmic protein that associates with the 40S ribosomal subunit (Parsyan 2009)
  • plays a prominent role in the translation of mRNAs with highly structured 5prime UTRs (Parsyan 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
  • ATP binding
  • protein
  • binds 40S subunits and hydrolyzes ATP, GTP, UTP, and CTP (Pisareva 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    caused dissociation of polysomes, with a concomitant increase in the abundance of 80S ribosomes as well as 40S and 60S subunits (Parsyan 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target translational inhibition through DHX29 silencing might present a means by which cancer cell growth could be inhibited (Parsyan 2009)
    ANIMAL & CELL MODELS