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FLASH GENE
Symbol RASGRP3 contributors: mct - updated : 22-08-2014
HGNC name RAS guanyl releasing protein 3 (calcium and DAG-regulated)
HGNC id 14545
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver    
Nervousbrain   highly
Reproductivefemale systemplacenta   
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one N-terminal Ras-GEF domain
  • two EF-hand calcium binding motifs
  • one zinc-dependent diacylglycerol/phorbol ester binding domain (C1 domain)
  • HOMOLOGY
    interspecies homolog to murine LOC240168
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text redistributed to perinuclear regions in response to phorbol ester treatment
    basic FUNCTION
  • GTPase activator activity
  • guanyl-nucleotide exchange factor activity
  • signal transducer activity
  • serves as a PKC-independent pathway to link the tumor-promoting phorbol esters with activation of Ras GTPases
  • implicated in phorbol ester-induced, PKC-independent exocytosis
  • exchange factor for Ras-like small GTPases that is activated in response to the second messenger diacylglycerol
  • mediates the activation of the Ras signaling pathway that is present in many human cancers
  • contributes to developmental defects found in embryos that develop in a diabetic environment
  • activator for HRAS, RRAS and Ras-associated protein-1/2, has emerged as an important mediator of signaling downstream from receptor coupled phosphoinositide turnover in B and T cells
  • its role in melanoma highlights its importance, as a RAS activator, in the phosphoinositide signaling pathway in melanoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Ca2+ binding
  • DAG binding
  • protein
  • also activates RAP1A, which in some cases can antagonize the function of RAS (RAP1A can antagonize the function of RAS, and DGKI regulates RASGRP3 with a predominant effect on RAP1A activity)
  • DYNLL1 is a RASGRP3-interacting protein (interaction required the C-terminal domain encompassing the last 127 AAs of RASGRP3)
  • RASGRP1, RASGRP3 may regulate progenitor entry into the thymus through a CCR9-dependent mechanism
  • cell & other
    REGULATION
    Other regulated by calcium and diacylglycerol binding
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductionpregnancy 
    may be a novel therapeutic target for the fetal complications of diabetes
    cancerreproductiveprostate
    may constitute a novel therapeutic target for human prostate cancer
    ANIMAL & CELL MODELS