basic FUNCTION
| GTPase activator activity |
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guanyl-nucleotide exchange factor activity |
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signal transducer activity |
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serves as a PKC-independent pathway to link the tumor-promoting phorbol esters with activation of Ras GTPases |
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implicated in phorbol ester-induced, PKC-independent exocytosis |
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exchange factor for Ras-like small GTPases that is activated in response to the second messenger diacylglycerol |
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mediates the activation of the Ras signaling pathway that is present in many human cancers |
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contributes to developmental defects found in embryos that develop in a diabetic environment |
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activator for HRAS, RRAS and Ras-associated protein-1/2, has emerged as an important mediator of signaling downstream from receptor coupled phosphoinositide turnover in B and T cells |
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its role in melanoma highlights its importance, as a RAS activator, in the phosphoinositide signaling pathway in melanoma |