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FLASH GENE
Symbol TFEC contributors: mct - updated : 03-09-2013
HGNC name transcription factor EC
HGNC id 11754
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines monocytic leukemia cell line
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a basic helix-loop-helix (bHLH) domain
  • a lecuine zipper domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Tcfec
    homolog to rattus Tfec
    intraspecies paralog to MITF
    Homologene
    FAMILY MItf-Tfe family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • can activate or inhibit promoters of melanocyte-specific tyrosinase and the heme oxygenase-1 gene (HMOX1) depending on cell type
  • sequence-specific transcriptional activator of the non muscle myosin heavy chain A gene
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding a CANNTG motif (E box)
    RNA
    small molecule
    protein
  • TFE3 and TFEC proteins may collaborate with MITF to efficiently regulate expression of target genes in osteoclasts
  • in conjunction with MITF/TFEC, PAX6 acts as an anti-retinogenic factor, whereas in conjunction with retinogenic genes it acts as a pro-retinogenic factor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS