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FLASH GENE
Symbol UMPS contributors: mct - updated : 22-05-2013
HGNC name uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)
HGNC id 12563
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
Lymphoid/Immunelymph node   moderately
Reproductivefemale systemovary  moderately
 female systemplacenta  moderately
 female systemuteruscervix highly
Skin/Tegumentskin   moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
Muscular    
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus Umps_predicted
ortholog to murine Umps
Homologene
FAMILY
  • purine/pyrimidine phosphoribosyltransferase family (for the N ternimal region)
  • OMP decarboxylase family (for the C ternimal region)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • acting as an orotate phosphoribosyltransferase
  • acting as an orotidine-5'-phosphate decarboxylase
  • involved in early events of pancreatic and gallbladder carcinogenesis and invasion of involved in early events of pancreatic and gallbladder carcinogenesis and invasion of HCC.
  • fundamental enzyme in pyrimidine synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
  • pyrimidine biosynthesis
  • UMP biosynthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) UMPS , ODC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hormone-refractory prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • high UMPS expression predicts complete response to chemoradiotherapy in patients with squamous cell carcinoma of the esophagus
  • Therapy target
    ANIMAL & CELL MODELS