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FLASH GENE
Symbol IFNR contributors: mct - updated : 28-05-2014
HGNC name interferon production regulator
HGNC id 5447
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
mono polymer heteromer , dimer
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
basic FUNCTION unknown
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
  • heterodimer composed of two transmembrane chains, IFNAR1 (interferon-alpha receptor 1 subunit) and IFNAR2, which are associated with the tyrosine kinases TYK2 and JAK1 (Janus kinase 1) respectively
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • COPS5 acts potentially as a positive regulator of IFN responses by stabilizing IFNR through antagonizing the NEDD8 pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS