| basic FUNCTION
| transforming growth factor, involved in mitogenesis and angiogenenesis |
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able to bind to the EGF receptor and to act synergistically with TGF beta to promote anchorage-independent cell proliferation |
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major autocrine EGF receptor ligand  |
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having an EGFR-independent action, in which it protects NKD2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells |
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influence risk of CL/P through unconventional means with an apparent parent-of-origin effect (excess maternal transmission) and possible interaction with maternal exposures |
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TGFA and EREG lead to complete receptor recycling, and AREG does not target EGFR for lysosomal degradation but causes fast as well as slow EGFR recycling |
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EGF and TGFA retain some level of functional redundancy, possibly resulting from their divergence from a common ancestral gene |
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may attenuate hepatic fibrosis in part because of upregulation of the expression of MMP1 |
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MMP9 expression induced by TGFA is a valid target of PPARD ligands in keratinocytes |
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appears to be an important growth factor regulating the conversion of cartilage to bone during the process of endochondral ossification |
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increased proliferation and migration of pancreatic stellate cells (PSCs), and TGFA-induced migration of cells may be partly due to upregulation of MMP1 |
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play multifunctional roles in the central nervous system (CNS), including the provision of neurotropic properties that protect neurons against various neurotoxic insults |
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modulates epithelial-mesenchymal transition (EMT) markers and NFKB signaling pathway in colon cancer cells |
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during head and neck development, IRF6 is involved in the structure formation of the oral and maxillofacial regions, and TGFA is an essential cell regulator, acting during proliferation, differentiation, migration and apoptosis |
