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FLASH GENE
Symbol GIPC3 contributors: mct - updated : 24-08-2010
HGNC name GIPC PDZ domain containing family, member 3
HGNC id 18183
EXPRESSION
Rna function mRNA ubiquitously expressed in normal adult tissues as well as in normal fetal tissues (Saitoh 2002)
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestinejejunum highly
Lymphoid/Immunelymph node   highly
Nervousbrainforebraincerebral lobeparietal lobe 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text
  • eyes, lens, eye anterior segment, optic nerve, retina foveal and macular, RPE and choroid
  • fetal spleen, and fetal thymus
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a central PDZ domain, which interact with Frizzled-3 (FZD3) class of WNT receptor, insulin-like growth factor-I (IGF1) receptor, receptor tyrosine kinase TrkA, TGF-beta type III receptor (TGF-beta RIII), integrin alpha6A subunit, transmembrane glycoprotein 5T4, and RGS19/RGS-GAIP (Katoh 2002)
  • GIPC homology (GH1 and GH2) domains
  • HOMOLOGY
    intraspecies homolog to GIPC1, GIPC2
    Homologene
    FAMILY
  • GIPC family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in g protein-linked signaling
  • might play key roles in carcinogenesis and embryogenesis through modulation of growth factor signaling and cell adhesion (Katoh 2002)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB72
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS