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FLASH GENE
Symbol GBP5 contributors: mct - updated : 01-10-2014
HGNC name guanylate binding protein 5
HGNC id 19895
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Reproductivefemale systembreast   
 male systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymhoid/Immunelymphocyte
Respiratoryalveolar macrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal part, that carries the geranylgeranylation motif , C-terminal CaaX-prenylation signal, which is typical for small GTPases of the Ras family, and increases the membrane affinity of proteins
  • HOMOLOGY
    Homologene
    FAMILY interferon-gamma-inducible large GTPases family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • GBP1, GBP3, and GBP5 were exclusively detected in the cytoplasm, whereas GBP2 and GBP4 displayed a nucleocytoplasmic distribution
  • prenylated and prenylation is required for the membrane association
  • basic FUNCTION
  • may be involved in immune response and have cancer-related functions
  • GBP1, GBP2 and GBP5 were able to redirect non-prenylated GBPs to their compartment in a prenylation-dependent manner
  • promoted selective NLRP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents
  • serves as a unique rheostat for NLRP3 inflammasome activation and extends our understanding of the inflammasome complex beyond its core machinery
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GBP5 promotes CASP1–mediated protection against oral Listeria infection and NLRP3-dependent inflammatory responses
  • cell & other
    REGULATION
    induced by robustly induced only by IFN-gamma and not by TNF-alpha and IL-1beta
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS