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FLASH GENE
Symbol FAT3 contributors: mct - updated : 30-10-2015
HGNC name FAT tumor suppressor homolog 3 (Drosophila)
HGNC id 23112
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousspinal cord    
cell lineage
cell lines tumor cell lines
fluid/secretion
at STAGE
physiological period embryo
Text late embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cadherin domain
  • epidermal growth factor (EGF)-like motif
  • a laminin A-G motif and a cytoplasmic domain
  • conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
  • FAT3 family
  • CATEGORY secretory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing an important role in axon fasciculation and modulation of the extracellular space surrounding axons during embryonic development
  • atypical cadherin FAT3 ensures that amacrine cells develop this unipolar morphology
  • FAT3 and FAT4 synergize potentially to drive vertebral arch fusion at the dorsal midline during caudal vertebra morphogenesis
  • FAT3 and DCHS2 are required for cartilage stacking and polarity, consistent with a role in planar cell polarity (PCP), and are also required for cartilage differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FAT3, and its partner DCHS2, control polarized cell-cell intercalation of cartilage precursors during craniofacial development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS