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FLASH GENE
Symbol ANTXR2 contributors: mct/npt - updated : 04/10/2008
HGNC name anthrax toxin receptor 2
HGNC id 21732
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
Lymphoid/Immunespleen    
Reproductivefemale systemplacenta  highly
 female systemuterus  highly
Respiratoryrespiratory tracttrachea  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye, spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one VWFA domain
  • N-terminal signal sequence
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • ATR family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text type 1 membrane protein
    basic FUNCTION
  • involved in normal cell interactions with the extracellular matrix
  • playing a role in basement-membrane-matrix homeostasis and achitecture during development and morphogenesis
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS cardiovascular
    text overexpressed in endothelial cells during capillary formation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to collagen IV and laminin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) JHF
    Susceptibility to ankylosing spondylitis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS