SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
|
| intracellular,cytoplasm,organelle,mitochondria
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
basic FUNCTION
| may be involved in proteolysis and peptidolysis |
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with SPPL2B mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the ITM2B N-terminal fragment |
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important role for the final step in the CD74-MHC II pathway and a new target for protease inhibitor treatment of B cell diseases |
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enzyme controlling turnover and functions of the invariant chain (CD74) of the MHCII complex, with critical importance of this process for B cell development |
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presenilin-homologue residing in lysosomes/late endosomes, cleaving type II-oriented transmembrane proteins |
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is critical for formation of dental enamel, and intramembrane proteolysis by SPPL2A is essential for maintaining cellular homeostasis of ameloblasts |
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distinct functions of SPPL2A and SPPL2B and, high abundance of SPPL2B in brain suggests a physiological role of this protease in the central nervous system |
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SPPL2A and SPPL2B have been implicated in regulated intramembrane proteolysis (RIP) of type II transmembrane proteins |