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FLASH GENE
Symbol SHPRH contributors: mct/npt - updated : 08/11/2008
HGNC name SNF2 histone linker PHD RING helicase
HGNC id 19336
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two partial SNF2 domains and 1 each of PHD finger, RING finger, linker histone
  • DEAD helicase domains
  • a nuclear localization signal
  • HOMOLOGY
    interspecies ortholog to yeast Rad5
    Homologene
    FAMILY
  • SNF2/rRAD54 helicase family
  • CATEGORY transcription factor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • may be playing a role in chromatin-mediated transcriptional regulation
  • possible candidate for the tumor suppressor gene
  • HLTF and SHPRH suppress mutagenesis in a damage-specific manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    RAD5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with PCNA, RAD18, and the ubiquitin-conjugating enzyme UBE2N and promotes methyl methanesulfonate (MMS)-induced PCNA polyubiquitination
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS