basic FUNCTION
| may be playing a role in granulocyte and macrophage development leading to inflammation and immune response |
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may be mediating gene expression by regulating arginine methylation and citrullination in histones |
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catalyzing the post-translational citrullination of proteins |
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playing a role in the regulation of TP53 target gene expression |
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citrullinated the histone chaperone protein, nucleophosmin (NPM1), at the arginine 197, and citrullination of NPM1 by PADI4 resulted in its translocation from the nucleoli to the nucleoplasm |
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promotes the deimination of arginine residues in histones and may regulate transcription in the context of the chromatin |
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converts peptidyl arginine to citrulline in histone H3 and can repress gene expression |
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catalyze the hydrolysis of peptidyl-arginine to form peptidyl-citrulline, and play important roles in a variety of cell signaling pathways, including apoptosis, differentiation, and transcriptional regulation |
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autodeimination of PADI4 alters protein-protein interactions but not activity |
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homodimeric enzyme that catalyzes CaČ& |
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8314;-dependent protein citrullination, which results in the conversion of arginine to citrulline |
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protein citrullination by PADI4 thus emerges as a novel mechanism for controlling a de novo DNA methyltransferase |
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PADI4 is an enzyme implicated in citrullination in the Rheumatoid arthritis (RA) synovium |
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catalyzes the deimination of histone arginine residues to citrulline |
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HIF-dependent recruitment of PADI4 to target genes and local histone citrullination are required for transcriptional responses to hypoxia |
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accelerate metastasis by promoting IL-8 expression in gastric cancer cells |
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PADI4 is dispensable for cell-autonomous HSC maintenance, differentiation and haematopoietic regeneration |