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FLASH GENE
Symbol HECTD1 contributors: mct - updated : 29-08-2018
HGNC name HECT domain containing 1
HGNC id 20157
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemplacenta    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmooth   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one HECT domain
  • HOMOLOGY
    Homologene
    FAMILY
  • UPL family
  • K-HECT subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • in trophoblast giant cells (TGCs) and other trophoblast-derived cell subtypes in the junctional and labyrinth zones of the placenta
  • basic FUNCTION
  • involved in protein modification, ubiquitin cycle
  • HECTD1 function is required at a critical threshold for neural tube closure
  • is a functional ubiquitin ligase
  • HECTD1 promotes the APC-AXIN1 interaction to negatively regulate WNT signaling
  • is required for development of multiple cell types within the junctional zone of the placenta
  • is involved in ABCA1-mediated cholesterol export from macrophages
  • control of MACF1 levels by HECTD1 modulates likely epithelial-to-mesenchymal transition (EMT) and the efficiency of metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrates of HSP90AA1
  • Condensins positively regulate ligand-dependent enhancer activation at least in part by recruiting HECTD1, to modulate the binding of enhancer-associated coactivators/corepressors, including NRIP1
  • regulates the protein level of IQGAP1 through ubiquitination and therefore mediates the dynamics of focal complexes (FXs) including the recruitment of paxillin and actinin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    results in mid-gestation lethality and intrauterine growth restriction (IUGR)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS