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FLASH GENE
Symbol AURKAIP1 contributors: mct/npt - updated : 16-03-2009
HGNC name aurora kinase A interacting protein 1
HGNC id 24114
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunethymus    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a tandem bipartite nuclear localization signal
  • HOMOLOGY
    interspecies homolog to rattus Akip
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text colocalized with Aurora-A and GSK-3beta to the spindle poles in metaphase
    basic FUNCTION
  • positive regulator of proteolysis
  • could be a potential useful target gene for anti-tumor drugs
  • involved in the destabilization of Aurora-A through the proteasome-dependent degradation pathway (Lim (2007)
  • functions in stabilizing rather than destabilizing Aurora-A (Katayama 2007)
  • promotes proteasome-dependent Aurora-A degradation through an Ub-independent mechanism (Lim 2007)
  • palying a a role for AIP in G2/M cell cycle progression by cooperatively regulating protein stabilization of its up-stream regulator, Aurora-A kinase through protein-protein interaction as well as protein phosphorylation (Katayama 2007)
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with aurora A (targets Aurora-A for degradation in a proteasome-dependent but Ub (ubiquitin)-independent manner and inhibits polyubiquitination of Aurora-A)(Lim 2007)
  • negative regulator of Aurora-A, and a binding partner of GSK-3beta (GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AURKAIP1)(Fumoto 2008)
  • interacting with OAZ1 (might function upstream of the OAZ1 by enhancing the binding affinity of OAZ1 to Aurora-A to promote recognition, targeting to proteasome and subsequent degradation) (Lim 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS