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FLASH GENE
Symbol AGTRAP contributors: SGE/npt - updated : 05-10-2009
HGNC name angiotensin II receptor-associated protein
HGNC id 13539
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivesalivary gland   highly
Endocrinepancreas   highly
 thyroid   highly
Nervousnervecranial nerve  highly
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousoptic nerve
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Agtrap (75.5pc)
homolog to murine Agtrap (77.4pc)
Homologene
FAMILY
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • playing a role in the recycling of the AT(1) receptor to the plasma membrane with presumable concomitant recovery of receptor signal functions
  • negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation or by receptor desensitization such as phosphorylation
  • inducing also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity
  • downregulating AT1R and attenuating certain angiotensin II-mediated hypertrophic responses in cardiomyocytes (Tanaka 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1
  • interaction with CAMLG may mediate the AGT actions in vascular physiology
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS