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FLASH GENE
Symbol ZC3H3 contributors: - updated : 22-06-2004
HGNC name zinc finger CCCH type domain containing 3
HGNC id 28972
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuteruscervix highly
 female systemovary   
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a domain with five CCCH-type zinc fingers
HOMOLOGY
interspecies homolog to murine Zc3hdc3
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • displaying CPSF4-like activities, interacting in the nucleus with activated Smads, and potentiating in TGF-beta stimulated cells SMAD-dependent transcriptional responses, possibly in conjunction with the activity of CPSF complexes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to SMAD proteins (cooperate and enhance TGF-beta mediated activation of a Smad-responsive reporter gene)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS