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FLASH GENE
Symbol SEC31A contributors: mct - updated : 29-06-2018
HGNC name SEC31 homolog A (S. cerevisiae)
HGNC id 17052
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestiveintestinesmall intestine  moderately
Lymphoid/Immunelymph node   highly
Nervousbrain   moderately
Reproductivefemale systemplacenta  highly
 female systembreastmammary gland moderately
 male systemtestis  highly
 male systemprostate  moderately
Skin/Tegumentskin   moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
Muscular    
Nervousperipherous   
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus Sec31l1
ortholog to murine Sec31l1
homolog to yeast Sec31 protein
Homologene
FAMILY
  • WD repeat SEC31 family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • COPII vesicle coat
  • colocalized with SEC13
  • PAQR3 enhances Golgi localization of SEC13 and SEC31A
  • basic FUNCTION
  • required for ER-Golgi transport
  • colocalize with SEC13, one of the other components of COPII, in the subcellular structures corresponding to the vesicle transport function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text endoplasmic reticulum to golgi vesicle-mediated transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDCD6
  • bound ALG2, in a Ca(2+)-dependent manner and colocalized with ALG2 at ER exit sitestarget for PDCD6 (Yamasaki 2006)
  • binding of PDCD6 to SEC31A and inhibition of COPII vesicle budding is furthermore dependent on an intact Ca(2+)-binding site at EF-hand 1 of PDCD6
  • PDCD6/SEC31A interactions were not required for the localization of SEC31A to ER exit sites per se but appeared to acutely regulate the stability and trafficking of the cargo receptor p24 and the distribution of the vesicle tether protein p115
  • ANXA11, physically associates with SEC31A by the adaptor function of PDCD6
  • PDCD6 binding with SEC31A
  • USP8 interacts with and deubiquitinates SEC31A; the interaction was mediated by the adaptor protein STAM
  • N-terminal end of PAQR3 can interact with the WD domains of SEC13 and SEC31A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    fused with ALK, in a translocation t(2;4)(p23;q21), in an intraabdominal inflammatory myofibroblastic tumor
    tumoral fusion      
    SEC31A-ALK, in lung carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • SEC31A-ALK fusion transcript in clinical NSCLC, could be a novel diagnostic and therapeutic target for patients with non-small cell lung carcinoma (NSCLC)
  • Therapy target
    ANIMAL & CELL MODELS