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FLASH GENE
Symbol NSF contributors: - updated : 18-07-2006
HGNC name N-ethylmaleimide-sensitive factor
HGNC id 8016
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Endocrineneuroendocrinepituitary  highly
Nervousbrain   predominantly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two AAA family chaperone-like (adenosine triphosphatases associated with diverse cellular activities),
  • RNA helicase domain
  • mono polymer homomer , hexamer
    HOMOLOGY
    interspecies homolog to murine Nsf
    Homologene
    FAMILY AAA family of ATPases
    CATEGORY chaperone/stress , enzyme , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • involved in membrane fusion by hydrolysis ATP and subsequent dissociation of SNARE complex
  • recruited to the synaptic core (SNARE) complex at the site of fusion with NAPA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha-SNAP (SNAPA)
  • VAMP8
  • RAB-GTPase,STX7
  • RABGA,RAB3,RAB4
  • cell & other
    REGULATION
    activated by RAB3 and RAB4
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS