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FLASH GENE
Symbol ANTXR1 contributors: mct - updated : 05-06-2013
HGNC name anthrax toxin receptor 1
HGNC id 21014
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Hearing/Equilibriumearinnercochlea highly
Nervousbrain    
Respiratorylung    
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretoryalveolar epithelium highly
Epithelialabsorptive excretorydigestive epithelium (mucosa)  
Epithelialbarrier liningepidermis  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymhoid/Immunelymphocyte
Skin/Tegumentkeratinocyte
cell lineage
cell lines tumor endothelial cell line, not in normal blood vessels
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 293-AA extracellular domain with 3 putative end-length glycosylation sites, binding preferentially to collagen
  • a 23-AA putative transmembrane region followed by the short cytoplasmic tail
  • an extracellular von Willebrand factor type A (VWA) domain is located between residues 44 and 216
  • a segment in the cytoplasmic tail of ANTXR1 required for its association with the cytoskeleton
  • HOMOLOGY
    Homologene
    FAMILY ATR family
    CATEGORY storage
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • plays a positive role in endothelial cell activities related to angiogenesis
  • docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax
  • functioning as an adhesion molecule mediating cell spreading on immobilized protective antigen and collagen I
  • exists in different forms at the cell surface, a structure dependent on interactions with components of the actin cytoskeleton
  • developmentally controlled expression of ANTXR1 modulates endothelial cell response to canonical Wnt signaling to regulate vessel patterning and density
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in contrast to integrins, ANTXR1 does not use an adaptor to bind the cytoskeleton
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GAPOS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in tumor endothelial cells
    constitutional germinal mutation      
    in infantile hemangiomas, mutations resulting in increased interactions among KDR, ANTXR1, and beta 1 integrin proteins and in inhibition of integrin activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    ANTXR1 targeting may allow selective inhibition of pathological angiogenesis
    ANIMAL & CELL MODELS