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FLASH GENE
Symbol ORAI2 contributors: mct/npt - updated : 25-11-2009
HGNC name ORAI calcium release-activated calcium modulator 2
HGNC id 21667
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion blodd
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cytoplasmic C terminus required for its interaction with STIM1, and with three conserved glutamate mediating Ca(2+)-dependent inactivation (Lee 2009)
  • HOMOLOGY
    Homologene
    FAMILY
  • Orai family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in store-operated Ca(2+) entry (SOCE) with STIM1 and STIM2, ORAI1 and ORAI3 (Várnai 2009)
  • plasma membrane Ca(2+) channel that migrate and become tethered by STIM within the ER-PM junctions, where they mediate exceedingly selective Ca(2+) entry (Deng 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • dynamic interplay between 2 membrane proteins, STIM1 and 2 and ORAI1 to 3, underlies an intricate coupling between Ca2+ release from endoplasmic reticulum (ER) stores and Ca2+ entry across the plasma membrane (Wang 2009)
  • cell & other
    REGULATION
    inhibited by by extracellular Ca(2+) (DeHaven 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS