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FLASH GENE
Symbol AP2S1 contributors: mct - updated : 24-01-2023
HGNC name adaptor-related protein complex 2, sigma 1 subunit
HGNC id 565
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivestomach   highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
  • cultured leukemia cells
  • fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY clathrin adaptor complexes small chain proteins family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    text cytoplasmic face of coated vesicles
    basic FUNCTION
  • component of the adaptor complexes which link clathrin to receptors in coated vesicles
  • plays a role in the internalization of membrane proteins, including GPCRs
  • has a fundamental role in clathrin&
  • 8208;mediated endocytosis of G&
    8208;protein–coupled receptors (GPCR) such as the CASR
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • small chain component of the major clathrin adaptor complex AP2
  • heterotetramer composed of two large adaptins
  • (alpha1A/AP2A1 or alpha1B/AP2A1 or alpha2/AP2A2 and beta1/AP2B1), a medium adaptin (mu2/AP2M1) and
    a small adaptin (sigma2long/AP2S1 or sigma2short/AP2S1)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HHC3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS