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FLASH GENE
Symbol CENPQ contributors: mct/pgu - updated : 08-02-2013
HGNC name centromere protein Q
HGNC id 21347
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrineneuroendocrinepituitary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one putative coiled-coil domain (which does not correspond to a leucine zipper) from AA 155 to 203
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,centromere
    basic FUNCTION
  • MLF1IP and CENPQ are mutually required to localize to interphase and mitotic centromeres
  • phosphoregulation of CENPQ plays a central function in coordinating chromosome congression mechanisms (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constitutive centromere-associated network (CCAN) component
  • MLF1IP forms a binary complex with CENPQ, to promote their mutual stability and subcellular localization to interphase and mitotic centromeres
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLF1IP directly interacts with CENPQ, and this interaction was mutually required not only for their stability but also for their centromere localization
  • targets PLK1 to kinetochores and is also required for the recruitment of CENPE to kinetochores
  • cell & other
    REGULATION
    Phosphorylated by MLF1IP-bound PLK1 phosphorylates CENPQ
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS